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INCLUSION: Male/ Female 18-75 years of age Clinically definite, laboratory probable, or clinically probable ALS ALS symptom onset < 2 years prior to screening visit
INCLUSION: Male/Female 18-80 years of age Sporadic or familial ALS <24 months prior to screening SVC > 65% of predicted for age/height/sex EXCLUSION: At time
INCLUSION: Male/Female 18-80 years of age Sporadic or familial ALS Less than or equal to 18 months since ALS symptom onset. Slow Vital Capacity >60%
a. Subjects ≥12 years of age with a confirmed or suspected diagnosis of asthma or COPD b. Observational study only (no study medications)
a. Subjects 6-12 years of age with persistent asthma for at least 12 months b. At least 3 months of therapy on medium-dose inhaled corticosteroids
a. Subjects 18-75 years of age with severe asthma requiring medium to high-dose inhaled corticosteroids plus a second asthma controller in the previous 12 months
a. Subjects ≥12 years of age with severe asthma requiring medium to high-dose inhaled corticosteroids plus a second or third asthma controller b. Two or